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Due to structural connectivity and flexibility, many biological systems in meso-scale manifest interesting cooperative dynamics under the barriers caused by external fields, confining and constraining environments. Its cooperative dynamics is important, no only in understanding how a biological system self-organizes by manipulating its flexible degrees of freedom, but also in a multitude of biotechnological applications. Nature utilizes the ambient fluctuations in such biological soft-condensed matter to facilitate crossing seemingly insurmountable barriers, which is typically assisted by shape changes and coupling of the collective modes of the fluctuations. I will give a general introduction of biological soft-matter on meso-scales and nano-scales such as biopolymers, membranes and cells, and their physical features. Time permitting, I will talk about a number of subjects we have studied, such as biopolymer dynamics through membranes and potential barriers, bubble formation in double-stranded DNA, membrane fusion, and etc.